Motorists travelling through Harston on the A10 face a half hour detour to avoid a road closure of less than a mile.
Repair work on the High Street between Mill Road and London Road will see a 20 mile diversion put in place.
Cambridgeshire County Council said the closure is part of efforts to install a new share-use footway through the village.
The recommended diversion route would take motorists wanting to head north, down the A10 to Royston, along the A505 to Duxford and up the M11 towards Cambridge.
In order to complete improvement work for the new shared-use footway through Harston, the High Street will be closed between Station Road and London Road for two nights on Tues 8 and Wed 9 May. The road will be re-opened during the day. Please follow signed diversion route. pic.twitter.com/oo8SOHs8te
— Cambridgeshire CC (@CambsCC) May 4, 2018
The two night A10 closure will run from between 10pm to 6am on May 8 to 10. The road will be re-opened during the day.
Earlier this year motorists travelling through Littleport faced a 43-mile diversion for eight weeks – including on weekends – due to 'frustrating but necessary' road repairs.
In February a repair project on the A1101 Mildenhall road began part of a £6.25 million scheme to resurface roads across Cambridgeshire damaged by drought.